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Hypoglycemia: All sulfonylurea drugs are capable of producing severe hypoglycemia. Hypoglycemia is more likely to occur when caloric intake is deficient, after severe or prolonged exercise, when ethanol is ingested, or when more than one glucose-lowering drug is used. Hypoglycemia is also more likely in elderly or debilitated patients, malnourished patients and in patients with impaired renal or hepatic function, adrenal and/or pituitary insufficiency.
Hemolytic anemia: Sulfonylureas can cause hemolytic anemia in patients with glucose 6-phosphate dehydrogenase (G6PD) deficiency. Use with caution in patients with G6PD deficiency and consider use of nonsulfonylurea alternative.
Renal/Hepatic function impairment: Use with caution in hepatic or renal impairment as metabolism and/or excretion may be impaired. Dose reduction may be necessary.
Special Warnings and Precautions: This drug may elevate liver enzymes. Should be careful in patients who received this drug.
